Approximately 90% of diabetics have type 2 diabetes1,2,3
. Thus there is great interest in various animal models of type 2 diabetes. Available models express various characteristics of diabetes including insulin resistance, reduced insulin production, leptin resistance, etc.
The example below shows data from 6 fa/fa rats. The lean group of 3 rats were fed standard diet and the diabetic group of 3 rats were fed a high fat diet beginning two weeks prior to implantation. This data illustrates both the surgical recovery of the rats and the progressive onset of T2DM.
1. Diagnosis and Classification of Diabetes Mellitus, Diabetes Care January 2014 37:S81-S90; doi:10.2337/dc14-S081
2. National Diabetes Information Clearinghouse (NDIC): A service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH). http://diabetes.niddk.nih.gov/dm/pubs/overview/ (last updated Feb 5, 2014) 3. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. Geneva, World Health Organization, 1999 (WHO/NCD/NCS/99.2).