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A Continuous Glucose Telemetry Solution for Large Animals

The ability to collect continuous glucose, temperature, activity, and optionally blood pressure in large animals is possible through the use of DSI's PhysioTel Digital Telemetry system. A typical glucose system is comprised of 4-16 implants, 2-16 transceivers, 1-4 communication link controllers (CLC), and 1 computer running acquisition and analysis software.

How the system works

  • Implanted animals reside in their home cage with transceivers positioned on perpendicular cage walls.
  • The implant continuously measures glucose, temperature, activity, and blood pressure transmitting values out in real time.
  • The transceiver continuously listens to the transmitted signals and passes them along to the CLC.
  • The CLC passes this data on to a computer running acquisition and analysis software.
  • The acquisition portion of the software then records data from all animals.
  • The analysis portion of the software both analyzes incoming data in real time and can be used post-acquisition to refine the analysis based upon user inputs.
  • An independent glucose measurement device such as a glucometer is also required for periodic in-vivo calibration of the implant.Glucose measurements from that reference device can be entered into the software either in real-time or during later analysis.
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PhysioTel Digital System Hardware

The M series implants function with the PhysioTel Digital® telemetry platform using the following hardware:

  • PhysioTel Digital Transceiver (TRX)
    provides reliable reception of data transmitted via digital telemetry for a wide variety of species, animal sizes, and housing types.
  • Communication Link Controller (CLC)
    manages communication between the PhysioTel Digital implants and the acquisition computer. Maintains the digital data from implant to acquisition computer for optimal data integrity.
  • Computer with appropriate software installed
  • Networking Hardware enables the various pieces of hardware and software to communicate
    • Router - used to assign IP addresses.
    • Switch with PoE (Power over Ethernet) - used to power the hardware and allow multiple connections to the network.
Note: This same system supports all of our L series and M series PhysioTel Digital telemetry implants. In cases where a pressure measurement is made an ambient pressure reference called an APR-2 or both an APR-1 and E2S-1 are also required (and shown in the above diagram).

Software

M series continuous glucose telemetry implants are currently only supported in Ponemah version 6.41 and higher. 

  • Ponemah v6.x is ideal for PhysioTel, PhysioTel HD, and PhysioTel Digital implantable telemetry studies that do not require compliance with the Good Laboratory Practices (GLP).

DSI recognizes that many researchers interested in large animal glucose measurements desire or require GLP compliance to FDA 21 CFR Part 11 and we expect to offer such a software solution in the future.


On-demand Webinar

An essential webinar for researchers interested in collecting a complete glucose profile via implantable telemetry to minimize animal stress and improve animal welfare. Watch it Now

 

 

M0G - Glucose, Temperature, and Activity for Large Animals
M0G

M1G - Pressure, Glucose, Temperature, and Activity for Large Animals


M1G