Buxco® Head-out Plethysmographs

HO 3chamber

Head-Out plethysmographs are used to study restrained, conscious subjects.  It is the most cost-effective solution for measuring basic respiratory endpoints. It is a very reliable and simple method due to the direct measurement of air being displaced by the test subject’s expanding and contracting thorax. When using a head-out chamber, no other peripheral equipment is required such as temperature sensors, humidity sensors or bias air flow which significantly reduces the system cost. 

The Head-Out plethysmography system is ideal for researchers interested longitudinal studies without the use of anesthesia. Chambers are also compatible with other data acquisition systems including DSI Ponemah, which allows for the addition of telemetry endpoints to be collected simultaneously. The rat chamber has been designed specifically for the demanding Safety Assessment environment. 

Key Features:

  • Supported Species: Mouse Pup, Mouse, Rat (3 sizes), Rabbit, NHP
  • Continuously measures respiratory flow signals in conscious animal
  • Chambers utilize easy to operate restraint systems and integrated pneumotach
  • Up to 8 chambers can be measure simultaneously with one Buxco amplifier
  • Multiple amplifiers can be simultaneously interfaced with one software license
  • Low noise, 24 bit A/D amplifier design with USB interface to computer

Key Benefits:

  • Patented Allay™ Restraint - secures the animal without compressing the thorax (Mouse & Rat)
  • Patented Halcyon® pneumotach noise suppression design improves signal morphology*
  • Species flexibility – software, amplifier and transducers support all Head-Out chamber designs
  • FinePointe Software – integrated study design and subsequent automated reporting
  • Solid State Flow Transducer – small, rugged, low drift, high fidelity transducer mounts directly to chamber

* Not included on all chamber designs

Buxco Head-Out Chamber Details (Custom designs available upon request)

  • View Mouse Pup Head-Out Chamber

  • View Mouse Head-Out Chamber

  • View Rat Head-Out Chamber

  • View Rabbit Head-Out Chamber

  • View NHP Head-Out Chamber

HO Derived Parameters

  • Derived Parameters Table

Photo Gallery of Head-Out Chamber Accessories

Applications & References

Sibley L, Dennis M, Sarfas C, White A, Clark S, Gleeson F, McIntyre A, Rayner E, Pearson G, Williams A, Marsh P, Sharpe S. “Route of delivery to the airway influences the distribution of pulmonary disease but not the outcome of Mycobacterium tuberculosis infection in rhesus macaques. Tuberculosis. 2016;96:141-149.
Head out plethysmography articles citing DSI in Google Scholar
Head Out - Key Features
Invasive Non-Invasive
Restrained Un-Restrained*
Acute Longitudinal
Small Animal Large Animal
End Points
Rate / Volumes / Flows
Lung Characterization
Integrated Drug Delivery Methods
Tethered Infusion
Common Applications
Model Development
Treatment Assessment
Apnea & Breath Scoring
Sleep Apnea
Central Apnea
Chronic Bronchitis
Lung Fibrosis
Pulmonary Fibrosis
Cystic Fibrosis
Safety Assessment
Safety Pharmacology
Acute Respiratory Disorders
Respiratory Depression
Respiratory Syncytial Virus (RSV)
Acute Respiratory Distress Syndrome (ARDS)
Mucociliary Clearance and Dysfunction
Tuberculosis (TB)
Bronchiolitis/ Bronchitis 

View Rat Head Out Plethysmography Details