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Combined Applications

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DSI solutions have been used in combination with many other technologies for various research applications in both small and large animal models. Below are examples of combined techniques researchers have used. If you would like to discuss your application, click the schedule a free consultation button below. 
Synchronize implantable telemetry with hardwired data by using DSI's products listed below.

Implantable Telemetry
Signal Conditioners and Amplifiers
 


Whole Body Plethysmography and Telemetry 

Whole body plethysmography (WBP) and telemetry remain the recommended techniques for obtaining physiological assessments in small animals. Combining respiratory WBP with cardiovascular or CNS telemetry endpoints, including blood pressure, ECG, EEG and EMG, provides researchers looking at holistic effects and multi organ interactions with powerful data from one subject. 



Benefits:
  • Obtain both respiratory and cardiovascular endpoints
  • Longitudinal study approaches
  • Understand the interactions between organ systems
  • Utilize the same Ponemah software platform

Examples of applications that benefit from this integrated approach include: 
  • Sleep apnea
  • Earlier drug development safety assessments
  • Circadian Rhythm
  • Cardiorespiratory interactions 
  • Heart failure
  • Spinal injury
  • Anxiety
  • Recreational and addictive drug effects
  • Epilepsy  



Tethered Applications and Whole Body Plethysmography 

Specially designed respiratory whole body plethysmographs (WBP) offer the flexibility to integrate tethered animal models; allowing the ability to combine technologies or have access to the animal while in the chamber.

  • Optogenetics - Neural control of breathing
  • Electrical Commutator - Collect hardwired biopotential (EEG, EMG, EOG) signals simultaneously
  • Fluid Swivel - Administer compound, manage pain, draw blood, or create an injury model

Suitable for mouse, rat, and guinea pig animal models

 
Benefits:
  • Stimulate or record using tethered technology
  • Vascular access for delivery or sampling
  • Understand the interactions between organ systems

Examples of applications that benefit from this integrated approach include: 
  • Sleep apnea
  • Respiratory depression
  • Pain management
  • Recreational and addictive drug effects
  • Cardiorespiratory stimulation
  • Hypoxia/hypercapnia effects
  • Anxiety
  • Epilepsy
  • Blood sampling / drug administration



Forced Exercise and Telemetry

Forced exercise is used by researchers to induce and study physiologic stress responses, as well as assess acute and chronic adaptation to exercise in particular genetic models and/or disease states. Treadmills are the preferred method over voluntary running wheels due to the standardization across all subjects and increased levels of stress hormones and cytokines. Studies are enhanced by integrating telemetry to measure cardiovascular endpoints, leading to a better understanding of the full response on the cardiovascular system. 



Treadmill

Benefits: 
  • Observe stress induced cardiovascular changes in real time 
  • Study acute stress response or chronic stress exposure
  • Physiological data and video synchronization 
  • New insight into forced exercise 

Examples of applications that benefit from this integrated approach include: 


Fear Conditioning and Telemetry

Forced immobilization is commonly used as a model of stress in small laboratory animals, especially for inducing physiological stress to mimic human situations in small enclosures (claustrophobia).  Researchers will look at this induced psychological stress and decipher the mechanisms involved in the adaptation to stress, as well as pathology/disease development. Combining telemetry with fear conditioning can provide real-time cardiovascular, temperature and/or glucose data that will show the physiological effects of psychological stress in acute and chronic studies. 


Benefits: 
  • Observe stress induced physiological changes in real time 
  • Study acute stress response or chronic psychological stress exposure
  • Full intensity motorization of the animal's emotional state during the psychological stress induction procedure

Examples of applications that would benefit from this integrated approach include: 


Metabolism and Cardiovascular Telemetry 

The link between metabolism and the cardiovascular system has been getting more attention in the 21st century with the increased rate of obesity and type two diabetes, and their link to cardiovascular disease. Researchers are using animal models to assess early, mid and late stage metabolic diseases, as well as metabolic circadian rhythm and hibernation trends. By adding hemodynamic parameters with metabolic and hibernation studies, researchers are able to assess blood pressure, ECG, blood glucose, temperature and activity in a single animal. The combination of these applications also helps to separate excitement responses due to room entry or food offering, and actual changes in blood glucose. DSI technology provides continuous glucose and cardiovascular telemetry data collection, providing a less stressed environment, leading to reliable and translatable data. 


Benefits: 
  • Observe real time physiologic data
  • Stress free data collection, leading to more accurate data
  • A more comprehensive picture of whole animal cardiovascular and metabolic physiology

Examples of applications that would benefit from this integrated approach include: